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Research Associate (Cellular Assays)

Company: Prelude Therapeutics Incorporated
Location: Wilmington
Posted on: November 22, 2021

Job Description:

Prelude Therapeutics is a biopharmaceutical company focused on discovery and development of innovative small molecule therapeutics targeting novel pathways for the treatment of cancer and rare diseases. Prelude has assembled a world-class team with a passion for scientific innovation and a commitment to developing novel therapies.Prelude offers a vibrant and collegial work environment and excellent career growth opportunities. Prelude is ideally located within 25 minutes from the Philadelphia International Airport at the Delaware Innovation Space, an emerging research campus in the DuPont Experimental Station.The Research Associate will contribute to the company's efforts to design and develop a pipeline of novel, orally bioavailable, small molecule therapies that target key drivers of cancer cell growth, survival, and drug resistance. The successful candidate will have a cell/molecular biology and informatics background and is able to work in a collaborative team environment, perform experiments, organizes, and analyzes results, and communicates effectively to support R & D teams.Responsibilities and Duties:

  • Evaluate potency and selectivity of new molecules in various functional and phenotypic cell-based assays.
  • Evaluate physiochemical properties of lead molecules such as stability, permeability, and solubility assessment.
  • Manage small molecule compound inventory.
  • Develop and optimize assay systems to support new programs.
  • Maintain laboratory equipment and restock supplies.
  • Maintain accurate records of experiments, analyze, and interpret the results, present summaries, and generate reports of the studies.
  • Work in close collaboration with chemistry and preclinical development teams and communicate results in a timely manner.Qualifications:
    • BS/BA or MS in Life Sciences, molecular/cell biology, or equivalent discipline with 1 - 3 years' experience in oncology or immunology research in industry or academic setting.
    • Experience in cell and molecular biology techniques, such as immunoblotting, ELISA, qPCR, and cell culture.
    • Hands-on experience with development of functional cellular assays, including tumor cell proliferation, differentiation, and apoptosis.
    • Experience with analytical chemistry techniques including solubility, pKA determination and familiarity with HPLC and LCMS/MS instruments.
    • Familiarity with data and compound management programs such as Dotmatics and Mosaic, a plus.
    • Should be proficient at conducting review of relevant scientific literature using Pubmed and other resources.
    • Should be highly independent and organized, with excellent verbal and written communication skills.Special Characteristics/Job Requirements:
      • Physical Activities: Reaching, Talking and Hearing.
      • Physical Requirements: Lab based responsibilities.
      • Visual Acuity Requirements: Close visual acuity required for activities such as: preparing and analyzing data and figures; viewing a computer terminal; and extensive reading.
      • Working Conditions: OnsitePrelude Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.Prelude Therapeutics, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Prelude, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Prelude shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.---*And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Prelude has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.*Job Type: Full-timePay: $1.00 - $2.00 per yearBenefits:
        • 401(k)
        • 401(k) matching
        • Dental insurance
        • Employee assistance program
        • Employee discount
        • Flexible spending account
        • Health insurance
        • Life insurance
        • Paid time off
        • Parental leave
        • Professional development assistance
        • Vision insuranceSchedule:
          • Monday to FridaySupplemental Pay:
            • Bonus payApplication Question(s):
              • Do you possess 1-3 years' hands-on experience with development of functional cellular assays, including tumor cell proliferation, differentiation, and apoptosis?Education:
                • Bachelor's (Required)Work Location: One location

Keywords: Prelude Therapeutics Incorporated, Wilmington , Research Associate (Cellular Assays), Other , Wilmington, Delaware

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